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June 1, 2020

Zoldonat is a prescription medication used to treat a number of bone diseases. This generic drug contains the active ingredient zoledronic acid, a type of medicine called a bisphosphonate. It can be used to:

  • Treat and prevent osteoporosis in postmenopausal women at risk of bone fracture.
  • Treat and prevent osteoporosis in men who are at high risk of bone fracture.
  • Treat and prevent osteoporosis in men and women who are on corticosteroid therapy such as prednisolone.
  • Treat bone disease known as Paget’s disease (characterized by excessive breakdown of bone and increased irregular formation of bones causing it to become deformed, enlarged, weak, painful, and prone to breaking).
  • Reduce the high calcium level in the blood caused by cancer that has spread to the bones
  • Treat bone pain and weakness caused by myeloma or breast cancer that has spread to the bones.
  • Help protect that bones from the effect of some treatment for early breast cancer.
  • Reduces the risk of early breast cancer from coming back.

Zoledronic acid was approved for medical use in the US since 2001. It is considered one of the safest and most effective drugs needed in the health system by the World Health Organization.

As a bisphosphonate, this medicine works by stopping the bone osteoclast from breaking down the bone and by reducing the turnover of the bone. Zoldonat binds very tightly to the bone and prevents the calcium from being removed by the osteoclasts. In postmenopausal women, the levels of estrogen in their blood start to decrease. As a result, there is an increase in the breakdown of the bone osteoclast which resulted in a loss of bone density.

Bone loss among menopausal women is particularly rapid for the first ten years. Over time, it may lead to the development of osteoporosis or the thinning of the bone. The bones become more porous and fragile. The result can be painful fractures. The loss of bones occurs progressively and silently, often time, there are no symptoms until the first fracture occurs.

When and How to Use Zoldonat

Zoledronic acid is given for over 15 minutes via a drip into a vein.

  • It’s given as a single dose once a year in treating osteoporosis in men and women. It’s also given as a single dose once a year in treating Paget’s disease along with 750 mg of calcium supplements twice a day and vitamin D every day.
  • For the treatment of multiple myeloma, osteolytic bone metastases of solid tumors, it’s given no less than 15 minutes every 3 to 4 weeks along with oral calcium supplement multivitamins containing 400iu of vitamin D every day.
  • If you are having this medication to prevent cancer from coming back, you need to have the infusion every 6 months for 3 to 5 years.
  • To strengthen your bones and reduce bone pain, you may have to take it as long as it is working. It may take 2 to 3 months before you can finally notice its full benefits.

The effect of this medicine is observed within a week of administration. The medicine remains active in the body for up to 28 to 32 hours after administration.

What to know before taking Zoldonat

  • Doctors must use Zoledronic acid with caution among people with:
    • Decreased kidney function
    • Decreased liver function
    • Who are dehydrated
    • Elderly people
    • Vitamin D deficiency
    • Who are receiving treatment with diuretics medications
    • Disorders of the parathyroid gland
  • Do not use among patients with:
    • Severely decreased kidney or liver functions
    • Low levels of calcium in the blood
    • Who are allergic to any of the bisphosphonate group of medicines
    • Pregnant or breastfeeding women
    • Children who are 18 years of age and below
  • This medicine can cause severe muscle and joint pain. If such symptoms happen, contact your doctor. Your doctor may advise you to discontinue the therapy.
  • You may also experience fever-like symptoms after the dose. If your fever-like symptoms do not resolve within 14 days, consult with your doctor.

Possible Side Effects of Zoldonat

Zoldonat may cause unwanted side effects aside from its needed effects. More common side effects are:

  • Chest pain
  • Agitation
  • Chills
  • Cough
  • Depression
  • Dizziness
  • Fever
  • Lower back or side pain
  • Nausea
  • Vomiting
  • Rapid weight gain
  • Pale skin
  • Headache
  • Bone pain
  • Disturbances in the gut
  • Red eyes
  • Pain in the hands and feet

Uncommon side effects are:

  • Tremor
  • Eye pain
  • Blurred vision
  • Anemia
  • Sleepiness
  • Loss of appetite
  • Shortness of breath
  • Acid reflux
  • Abdominal pain
  • Flushing
  • Increase in blood pressure
  • Feeling thirsty
  • Dry mouth

Getting the Best Result from Zoldonat

  • Your doctor will have to test your blood first to check the level of calcium before you can finally be given Zoldonat. After the IV transfusion, your doctor will want you to have a further blood test to monitor your blood calcium level.
  • The blood calcium level of those with Paget’s disease may drop for the first 10 days. They are required to take vitamin D supplements to prevent the calcium level from dropping. Symptoms of too low calcium in the blood include numbness, muscle spasm, tingling sensation in the area around the mouth.
  • Zoldonat is absolutely not recommended for pregnant nor breastfeeding women. Discuss with your doctor all the risks and benefits that you can get before having the transfusion.
  • This medication must be administered by a health care professional.
  • This medicine can cause a serious kidney problem especially if you’re taking diuretic, you have kidney disease or dehydrated. If you urinate less often than usual, have swelling in your ankles or feet, feeling short of breath than usual, call your doctor.
  • Call your doctor if you are experiencing numbness in your hands and feet, muscle spasm, hip pain, joint, and muscle pain.

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