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May 22, 2021

Domperidone is an antisickness medicine that is referred to as a dopamine antagonist. This is prescribed in several conditions. The medicine comes as a tablet for oral use.  


What condition does Domperidone treat? 

Domperidone is a prescription medicine used to relieve nausea and vomiting. It causes due to migraine, general anesthetics, or chemotherapyThis can also be used to prevent nausea and vomiting in people taking medications for Parkinson’s disease such as: 

  • Apomorphine 
  • Pramipexole 
  • Levodopa  

This prescription is also recommended by many doctors: 

  • For the treatment of stomach pain especially if you are having an end of life care or palliative care  
  • To increase milk supply if you are having trouble breastfeeding. This should only be used when other things have not worked.  


How does Domperidone work? 

Domperidone works mainly by stopping dopamine receptors that are found in the upper end of the digestive system. These reasons to: 

  • A tight muscle at the entry of the stomach 
  • An increased contraction of the muscles in the stomach  
  • Relaxation of the muscles at the exit of the stomach 

This speeds up the passage of food through the stomach down to the intestine which helps avoid vomiting. It also lessens the feeling of sickness, fullness, and bloating. Moreover, it prevents the food from flowing away through the stomach which stops reflux from occurring.  

This medication also blocks dopamine receptors in the chemoreceptor trigger zone (CTZ). CTZ is activated by nerve messages from the stomach once an irritant existsBy stopping the dopamine receptors in the CTZ avoids nausea messages from being directed to the vomiting center. As a result, this decreases the feeling of nausea and prevents vomiting.  


What is the dosage of Domperidone? 

Before you start taking this medication, your doctor must know if you: 

  • Are pregnant, trying for a baby, or breastfeeding 
  • Know you have any problems with your digestive system, such as internal bleeding or a blockage 
  • Have ever had an allergic reaction to any medicine 
  • Have problems with your kidneys or liver 
  • Have a tumor on your pituitary gland 
  • Have problems with your heart or if you have been told you have an irregular heart rhythm  

Take this medicine exactly as your doctor has prescribed. The recommended dosage for adults and young people aged 12 years or over is 10 mg. Each dose is to be taken up to three times a day. Do not take more than three dosages in any 24 hours. Take your medication about half an hour before meals/snacksIt will still work if you take this medicine after a meal, but it may take longer to affect. Domperidone must be taken for a short period only. Your treatment should not last longer than seven days. To help you remember, take it at the same time and in the same way each day. Do not suddenly stop this treatment without consulting your doctor.  


What are the precautions in using Domperidone? 

  • If you are taking or using any other medications, it is important to let your doctor know. This includes any medications you are taking which are available to buy without a prescription, as well as herbal and complementary medicines. 
  • Let your healthcare provider or pharmacists know if you are using this medicine for a child under 12 years of age.  
  • Domperidone is at times used to increase the milk supply. Conversely, there is some indication that it can give a baby an irregular heartbeat. Talk to a doctor about the benefits and possible risks of taking this medicine when breastfeeding. This medication is not usually recommended when breastfeeding, as it passes into breast milk in small amounts. Consult your doctor first before taking a dose of this drug.  
  • Some drugs and Domperidone can interfere with each other. This may increase your chance of having side effects. 
  • Domperidone is not usually recommended in pregnancy. 
  • Inform your doctor or pharmacist if you are taking medications for malaria, HIV infection, fungal infections, antidepressants, or having cancer treatment 
  • Let your doctor know right away if you have problems with your muscles or with your peeing as well as if your eyes start moving in an uncontrolled or unusual way. 
  • Domperidone may not be suitable for people over the age of 60. This is because there’s more risk of side effects.   

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